http://hdl.handle.net/10174/682 2026-04-03T19:33:58Z 2026-04-03T19:33:58Z BURKE, Anthony http://hdl.handle.net/10174/26591 2020-01-24T10:11:39Z 2019-08-14T23:00:00Z

Title: International Symposium on Synthesis and Catalysis 2019 Authors: BURKE, Anthony Editors: Burke, Anthony; Marques, Carolina; Carreiro, Elisabete Abstract: This is the book of abstracts for the 3rd edition of ISySyCat2019 that took place from 3 to 6 September 2019. http://isysycat2019.eventos.chemistry.pt/

2019-08-14T23:00:00Z Burke, Anthony Marques, Carolina Lawrence, Simon http://hdl.handle.net/10174/24681 2019-02-15T12:03:51Z 2018-03-01T00:00:00Z

Title: Pd-Catalyzed One-Pot Borylation/Intramolecular Asymmetric Arylation on α-Ketiminoamides: Innovative Approach to Chiral 3-Amino-2-oxindoles Authors: Burke, Anthony; Marques, Carolina; Lawrence, Simon Editors: List, Benjamin Abstract: 3-Amino-2-oxindole derivatives are a common framework found in many natural products and medicinal compounds and thus their synthesis is of significant importance. We report for the first time a one-pot approach for the synthesis of these compounds, using a borylation/intramolecular asymmetric arylation sequence starting from ortho-bromo-alpha-ketimino amide derivatives. Pd(OAc)(2) was used as the pre-catalyst along with (R)-BINAP as the chiral source. We successfully obtained a family of 3-phenyl-3-(aryl-amino)-indolin-2-one derivatives (11 in total) with excellent yields (up to 98%) and enantioselectivities of up to 76% ee. The reaction is versatile and tolerant of a wide range of functional groups.

2018-03-01T00:00:00Z Burke, Anthony Brandão, Pedro http://hdl.handle.net/10174/24676 2019-02-14T17:46:54Z 2018-09-19T23:00:00Z

Title: Recent advances in the asymmetric catalytic synthesis of chiral 3-hydroxy and 3-aminooxindoles and derivatives: Medicinally relevant compounds Authors: Burke, Anthony; Brandão, Pedro Editors: Motherwell, Willian; Zard, Samir Abstract: Several oxindole derivatives, of natural or synthetic origin, have been identified as medicinally appealing compounds, with a plethora of bioactivities reported. Chiral 3-hydroxy and 3-aminooxindole scaffolds have captured the attention of several research groups, due to their importance in drug discovery. In this review, we systematically address the wide variety of asymmetric catalytic methodologies employed in the preparation of these relevant chiral scaffolds, present in many biologically active compounds and/or natural products. Special focus will be given to the nature of the catalyst used.

2018-09-19T23:00:00Z Burke, Anthony Marques, Carolina Herrman, Gesine Turner, Nicholas http://hdl.handle.net/10174/24675 2019-02-14T17:45:06Z 2018-08-31T23:00:00Z

Title: Active Pharmaceutical Ingredients in Synthesis, Catalytic Processes in Research and Development Authors: Burke, Anthony; Marques, Carolina; Herrman, Gesine; Turner, Nicholas Abstract: Um livro sobre a aplicação de catalisadores na produção de moléculas biologicamente ativos e fármacos

2018-08-31T23:00:00Z