http://hdl.handle.net/10174/975 2026-04-04T14:32:56Z 2026-04-04T14:32:56Z Carreiro, Elisabete Costa, Ana Antunes, Célia Burke, AJ Pinto, F. Ernesto, S. Rodrigues, B. http://hdl.handle.net/10174/36782 2024-05-24T15:03:12Z 2023-11-09T00:00:00Z

Title: Quercetin-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer's Agents Authors: Carreiro, Elisabete; Costa, Ana; Antunes, Célia; Burke, AJ; Pinto, F.; Ernesto, S.; Rodrigues, B. Abstract: The number of patients with Alzheimer’s disease (AD) continues to rise and, despite the efforts of researchers, there are still no effective treatments for this multifaceted disease. The main objective of this work was the search for multifunctional and more effective anti-Alzheimer agents. Herein, we report the evaluation of a library of quercetin-1,2,3-triazole hybrids (I–IV) in antioxidant, hydrogen peroxide-induced oxidative stress protection, and cholinesterases (AChE and BuChE) inhibitory activities. Hybrids IIf and IVa-d showed potent in vitro inhibitory activity on eqBuChE (IC50 values between 11.2 and 65.7 µM). Hybrid IIf, the best inhibitor, was stronger than galantamine, displaying an IC50 value of 11.2 µM for eqBuChE, and is also a competitive inhibitor. Moreover, toxicity evaluation for the most promising hybrids was performed using the Artemia salina toxicity assay, showing low toxicity. Hybrids IIf, IVb, and IVd did not affect viability at 12.5 µM and also displayed a protective effect against oxidative stress induced by hydrogen peroxide in cell damage in MCF-7 cells. Hybrids IIf, IVb, and IVd act as multifunctional ligands in AD pathologies.

2023-11-09T00:00:00Z Carreiro, Elisabete Burke, A.J. Hermann, G.J. Federsel, H.-J. http://hdl.handle.net/10174/36781 2024-05-24T15:03:04Z 2023-08-15T23:00:00Z

Title: Continuous Flow Enantioselective Processes Catalysed by Cinchona Alkaloid Derivatives Authors: Carreiro, Elisabete; Burke, A.J.; Hermann, G.J.; Federsel, H.-J. Abstract: Without a doubt, asymmetric catalysis has been significantly enriched by the introduction of cinchona alkaloid derivatives. Moreover, such methods have been further enabled when used in conjunction with continuous flow systems. Besides being used in flow chemistry as organocatalysts, they also have been used as ligands or modifiers of metal catalysts. This has generally been accomplished via their immobilization on heterogeneous supports and incorporation into catalysis-enabling reactors or similar systems. In this minireview we look at the impact that cinchona-based catalysts and analogues have had on the field of continuous flow-chemistry during the last two decades or so.

2023-08-15T23:00:00Z Carreiro, Elisabete Fonseca, Daniela Amorim, Catarina Ramalho, JP Prates Hermann, Gesine Federsel , Hans-Jürgen Duarte, Ana Rita Burke, AJ http://hdl.handle.net/10174/36773 2024-05-24T15:00:43Z 2023-08-16T23:00:00Z

Title: Sustainable OrganoCatalyzed Enantioselective Catalytic Michael Additions in Betaine derived Deep Eutectic Solvents Authors: Carreiro, Elisabete; Fonseca, Daniela; Amorim, Catarina; Ramalho, JP Prates; Hermann, Gesine; Federsel , Hans-Jürgen; Duarte, Ana Rita; Burke, AJ Abstract: The organocatalyst cinchonidine-squaramide was immobilized within three different deep eutectic solvents (DESs): betaine:D-sorbitol:water, betaine: D-xylitol:water, and betaine:D-mannitol:water and evaluated in a well-known asymmetric Michael addition. These reactions provided excellent yields (up to 99%) and enantioselectivities (up to 98%) using only 1 mol% of organocatalyst. It was also possible to achieve 9 cycles in reactions with DES (betaine:D-sorbitol:water), proving the high recyclability of this system. In the reactions realized with only 0.5 mol% of organocatalyst, it was possible to achieve 5 cycles, and the products were obtained with high yields (up to 95%) and excellent enantioselectivities (up to 94%), using DES (betaine:D-sorbitol:water).

2023-08-16T23:00:00Z Alves, Victor Fdez-Riverola, Florentino Ribeiro, Jorge Neves, José Vicente, Henrique http://hdl.handle.net/10174/36770 2024-05-24T15:00:22Z 2024-01-01T00:00:00Z

Title: Encouraging Eco-Innovative Urban Development Authors: Alves, Victor; Fdez-Riverola, Florentino; Ribeiro, Jorge; Neves, José; Vicente, Henrique Abstract: This article explores the intertwining connections among artificial intelligence, machine learning, digital transformation, and computational sustainability, detailing how these elements jointly empower citizens within a smart city framework. As technological advancement accelerates, smart cities harness these innovations to improve residents’ quality of life. Artificial intelligence and machine learning act as data analysis powerhouses, making urban living more personalized, efficient, and automated, and are pivotal in managing complex urban infrastructures, anticipating societal requirements, and averting potential crises. Digital transformation transforms city operations by weaving digital technology into every facet of urban life, enhancing value delivery to citizens. Computational sustainability, a fundamental goal for smart cities, harnesses artificial intelligence, machine learning, and digital resources to forge more environmentally responsible cities, minimize ecological impact, and nurture sustainable development. The synergy of these technologies empowers residents to make well-informed choices, actively engage in their communities, and adopt sustainable lifestyles. This discussion illuminates the mechanisms and implications of these interconnections for future urban existence, ultimately focusing on empowering citizens in smart cities.

2024-01-01T00:00:00Z